Tocolytic Magnesium Sulfate Toxicity and Unexpected Neonatal Death
نویسندگان
چکیده
منابع مشابه
Evidence for magnesium sulfate as a tocolytic agent.
The objective of our study is to quantitatively examine the available evidence regarding the efficacy and side effects of magnesium sulfate for acute tocolysis (from randomized trials) compared with placebo and beta-agonist agents. Randomized trials comparing magnesium sulfate with placebo or beta-agonists for tocolysis were identified with a MEDLINE-based search and was supplemented by a searc...
متن کاملHigh dose magnesium sulfate exposure induces apoptotic cell death in the developing neonatal mouse brain.
BACKGROUND Magnesium sulfate (MgSO4) is often used as a treatment for pre-eclampsia/eclampsia and preterm labor, resulting in the exposure of a significant number of neonates to this drug despite a lack of evidence suggesting that it is safe, or effective as a tocolytic. While there is evidence that MgSO4 may be neuroprotective in perinatal brain injury, recent reviews have suggested that the e...
متن کاملNeonatal effects of magnesium sulfate given to the mother.
OBJECTIVE Magnesium historically has been used for treatment and/or prevention of eclampsia or preterm labor. More recently, antepartum magnesium sulfate has been suggested for prevention of cerebral palsy in preterm infants. Although adverse effects and toxicity of magnesium in pregnant women are well known, the fetal-neonatal effects of magnesium are less clear. The objective of this study wa...
متن کاملTocolytic magnesium sulfate exposure and risk of cerebral palsy among children with birth weights less than 1,750 grams.
The authors examined the relation between intrapartum magnesium sulfate exposure and risk of cerebral palsy in a case-control study of low birth weight children designed to control for confounding by the clinical indications for magnesium in pregnancy. Case children (n = 97) included all singleton children with cerebral palsy who were born in 1985-1989 in Atlanta, Georgia with a birth weight le...
متن کاملMagnesium Sulfate as a Second-Line Tocolytic Agent for Preterm Labor: A Randomized Controlled Trial in Kyushu Island
OBJECTIVES We evaluated the efficacy of magnesium sulfate as a second-line tocolysis for 48 hours. MATERIALS AND METHODS A multi-institutional, simple 2-arm randomized controlled trial was performed. Forty-five women at 22 to 34 weeks of gestation were eligible, whose ritodrine did not sufficiently inhibit uterine contractions. After excluding 12 women, 33 were randomly assigned to either ma...
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ژورنال
عنوان ژورنال: Journal of Perinatology
سال: 2001
ISSN: 0743-8346,1476-5543
DOI: 10.1038/sj.jp.7200498